Sugar-Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics

Siriwardena, Aloysius ; Pulukuri, Kiran Kumar ; Kandiyal, Pancham S. ; Roy, Saumya ; Bande, Omprakash ; Ghosh, Subhash ; Garcia Fernández, José Manuel ; Ariel Martin, Fernando ; Ghigo, Jean-Marc ; Beloin, Christophe ; Ito, Keigo ; Woods, Robert J. ; Ampapathi, Ravi Sankar ; Chakraborty, Tushar Kanti (2013) Sugar-Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics Angewandte Chemie International Edition, 52 (39). pp. 10221-10226. ISSN 14337851

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Official URL: http://doi.org/10.1002/anie.201304239

Related URL: http://dx.doi.org/10.1002/anie.201304239

Abstract

To fold or not to fold? It is shown that attached sugars play a defining role in the conformations adopted by a pair of novel SAA-derived foldamers in water and that these differences are reflected in the contrasting interactions of these glycofoldamers with various biological targets. C green, O red, N blue, H gray; yellow oval=mannose.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc.
ID Code:131115
Deposited On:02 Dec 2022 11:03
Last Modified:02 Dec 2022 11:03

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