Formal Synthesis of Actin Binding Macrolide Rhizopodin

Pulukuri, Kiran Kumar ; Chakraborty, Tushar Kanti (2014) Formal Synthesis of Actin Binding Macrolide Rhizopodin Organic Letters, 16 (8). pp. 2284-2287. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol5008179

Related URL: http://dx.doi.org/10.1021/ol5008179

Abstract

Formal synthesis of an actin binding macrolide rhizopodin was achieved in 19 longest linear steps. The key features of the synthesis include a stereoselective Mukaiyama aldol reaction, dual role of a Nagao auxiliary (first, as a chiral auxiliary of choice for installing hydroxy centers and, later, as an acylating agent to form an amide bond with an amino alcohol), late stage oxazole formation, and Stille coupling reactions.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:131112
Deposited On:02 Dec 2022 11:00
Last Modified:02 Dec 2022 11:00

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