Pulukuri, Kiran Kumar ; Chakraborty, Tushar Kanti (2014) Formal Synthesis of Actin Binding Macrolide Rhizopodin Organic Letters, 16 (8). pp. 2284-2287. ISSN 1523-7060
Full text not available from this repository.
Official URL: http://doi.org/10.1021/ol5008179
Related URL: http://dx.doi.org/10.1021/ol5008179
Abstract
Formal synthesis of an actin binding macrolide rhizopodin was achieved in 19 longest linear steps. The key features of the synthesis include a stereoselective Mukaiyama aldol reaction, dual role of a Nagao auxiliary (first, as a chiral auxiliary of choice for installing hydroxy centers and, later, as an acylating agent to form an amide bond with an amino alcohol), late stage oxazole formation, and Stille coupling reactions.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to American Chemical Society |
ID Code: | 131112 |
Deposited On: | 02 Dec 2022 11:00 |
Last Modified: | 02 Dec 2022 11:00 |
Repository Staff Only: item control page