Pal, Sudip ; Singh, Gajendra ; Singh, Shyam ; Tripathi, Jitendra Kumar ; Ghosh, Jimut Kanti ; Sinha, Sudhir ; Ampapathi, Ravi Sankar ; Chakraborty, Tushar Kanti (2015) Tetrahydrofuran amino acid-containing gramicidin S analogues with improved biological profiles Organic & Biomolecular Chemistry, 13 (24). pp. 6789-6802. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C5OB00622H
Related URL: http://dx.doi.org/10.1039/C5OB00622H
Abstract
Gramicidin S (GS) is a cyclic cationic antimicrobial peptide (CAP) with a wide spectrum of antibiotic activities whose usage has been limited to topical applications owing to its cytotoxic side effects. We have synthesized tetrahydrofuran amino acid (Taa)-containing GS analogues, and we have carried out conformational analysis and explored their structure activity relationships by evaluating their antitubercular, antibacterial and cytotoxic properties. Two of these analogues showed impressive as well as selective activity against Mycobacterium tuberculosis (MTB) without toxicity towards mammalian Vero cells or human RBCs, and are promising as potential leads.
Item Type: | Article |
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Source: | Copyright of this article belongs to Royal Society of Chemistry |
ID Code: | 131099 |
Deposited On: | 02 Dec 2022 10:32 |
Last Modified: | 01 Feb 2023 04:17 |
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