Synthesis of Amide-Linked Cyclic Dinucleotide Analogues with Pyrimidine Bases

Pal, Chandan ; Chakraborty, Tushar Kanti (2017) Synthesis of Amide-Linked Cyclic Dinucleotide Analogues with Pyrimidine Bases Asian Journal of Organic Chemistry, 6 (10). pp. 1421-1427. ISSN 21935807

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Official URL: http://doi.org/10.1002/ajoc.201700260

Related URL: http://dx.doi.org/10.1002/ajoc.201700260

Abstract

A convenient procedure has been developed for the synthesis of C2-symmetrical cyclic dinucleotide analogues that contain all-pyrimidine bases (cytosine, uracil and thymine) with amide bonds in place of natural phosphodiester linkages, starting from commercially available d-glucose diacetonide (GDA). The Vorbrüggen glycosylation of a common intermediate by using various pyrimidine bases was employed as the key step in the synthesis.

Item Type:Article
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ID Code:131086
Deposited On:02 Dec 2022 10:11
Last Modified:02 Dec 2022 10:11

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