Khan, Hina P. A. ; Chakraborty, Tushar Kanti (2020) Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to [a]-Annelated Indoles The Journal of Organic Chemistry, 85 (12). pp. 8000-8012. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/acs.joc.0c00817
Related URL: http://dx.doi.org/10.1021/acs.joc.0c00817
Abstract
An efficient and novel route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C–C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 131070 |
| Deposited On: | 02 Dec 2022 09:39 |
| Last Modified: | 02 Dec 2022 09:39 |
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