Jameel, Shahid ; Durgapal, Hemlata ; Habibullah, C. M. ; Khuroo, Mohammed Sultan ; Panda, Subrat Kumar (1992) Enteric non-A, non-B hepatitis: epidemics, animal transmission, and hepatitis E virus detection by the polymerase chain reaction Journal of Medical Virology, 37 (4). pp. 263-270. ISSN 0146-6615
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jmv.189...
Related URL: http://dx.doi.org/10.1002/jmv.1890370405
Abstract
We studied epidemics of viral hepatitis occurring at three different places in India. One was a combined epidemic due to hepatitis E virus (HEV) and hepatitis A virus (HAV) infections. In this epidemic, HAV affected children below 10 years of age, whereas HEV infected the young adult population. HEV was transmitted to rhesus monkeys (Macaca mulata) and confirmed by the polymerase chain reaction (PCR) on bile from the animals. Fecal material from acutely infected patients in one of the epidemics was also found positive for HEV RNA by PCR. This may help in confirming the nature of future epidemics. The bile and liver from experimental animals can be used as a source of material for further virological and molecular biological studies of HEV.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
Keywords: | HEV; PCR; Epidemic; Hepatitis; Bile; Transmission |
ID Code: | 13071 |
Deposited On: | 11 Nov 2010 06:56 |
Last Modified: | 23 Feb 2011 05:24 |
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