Dulle, Jana ; Thirunavukkarasu, K. ; Mittelmeijer-Hazeleger, Marjo C. ; Andreeva, Daria V. ; Shiju, N. Raveendran ; Rothenberg, Gadi (2013) Efficient three-component coupling catalysed by mesoporous copper–aluminum based nanocomposites Green Chemistry, 15 (5). p. 1238. ISSN 1463-9262
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Official URL: http://doi.org/10.1039/c3gc36607c
Related URL: http://dx.doi.org/10.1039/c3gc36607c
Abstract
Traditional synthesis methods for propargylamines have several drawbacks. A recently developed alternative route is the so-called “A3 coupling” in which an alkyne, an aldehyde, and an amine are coupled together. Typically, these reactions are catalysed by homogeneous gold salts, organogold complexes or silver salts. But these homogeneous catalysts are expensive and their separation is difficult. Here we report the discovery that solid Cu/Al/oxide mesoporous “sponges” are excellent A3 coupling catalysts. These materials are robust, inexpensive, and easy to make. They give good to excellent yields (87–97%) for a wide range of substrates. Being heterogeneous, these catalysts are also easy to handle and separate from the reaction mixture, and can be recycled with no loss of activity.
Item Type: | Article |
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Source: | Copyright of this article belongs to Royal Society of Chemistry. |
ID Code: | 130313 |
Deposited On: | 24 Nov 2022 06:18 |
Last Modified: | 24 Nov 2022 06:18 |
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