The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?

Kumar, Amresh ; Ladha, Amit ; Choudhury, Ankita ; Ikbal, Abu Md Ashif ; Bhattacharjee, Bedanta ; Das, Tanmay ; Gupta, Gaurav ; Sharma, Chhavi ; Sarbajna, Adity ; Mandal, Subhash C ; Choudhury, Manabendra Dutta ; Ali, Nahid ; Slama, Petr ; Rezaei, Nima ; Palit, Partha ; Tiwari, Onkar Nath (2022) The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19? Expert Review of Vaccines, 21 (8). pp. 1071-1086. ISSN 1476-0584

Full text not available from this repository.

Official URL: http://doi.org/10.1080/14760584.2022.2081156

Related URL: http://dx.doi.org/10.1080/14760584.2022.2081156

Abstract

Introduction: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the biggest global health issues. Spike protein (S) and nucleoprotein (N), the major immunogenic components of SARS-CoV-2, have been shown to be involved in the attachment and replication of the virus inside the host cell. Areas covered: Several investigations have shown that the SARS-CoV-2 nucleoprotein can elicit a cell-mediated immune response capable of regulating viral replication and lowering viral burden. However, the development of an effective vaccine that can stop the transmission of SARS-CoV-2 remains a matter of concern. Literature was retrieved using the keywords COVID-19 vaccine, role of nucleoprotein as vaccine candidate, spike protein, nucleoprotein immune responses against SARS-CoV-2, and chimera vaccine in PubMed, Google Scholar, and Google. Expert opinion: We have focussed on the use of chimera protein, consisting of N and S-1 protein components of SARS-CoV-2, as a potential vaccine candidate. This may act as a polyvalent mixed recombinant protein vaccine to elicit a strong T and B cell immune response, which will be capable of neutralizing the wild and mutated variants of SARS-CoV-2, and also restricting its attachment, replication, and budding in the host cell.

Item Type:Article
Source:Copyright of this article belongs to Taylor & Francis Group
Keywords:B cells; COVID-19; S-1 and N proteins; T cells; antibody; chimeric recombinant protein mixture; mutated variant of SARS-CoV-2; vaccine candidate
ID Code:130109
Deposited On:29 Nov 2022 03:45
Last Modified:29 Nov 2022 03:45

Repository Staff Only: item control page