Basavaiah, Deevi ; Mallikarjuna Reddy, Daggula (2012) Baylis–Hillman acetates in organic synthesis: convenient one-pot synthesis of α-carboline framework – a concise synthesis of neocryptolepine Organic and Biomolecular Chemistry, 10 (44). p. 8774. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C2OB26339D
Related URL: http://dx.doi.org/10.1039/C2OB26339D
Abstract
A convenient, facile, and one-pot methodology for the synthesis of α-carbolines from Baylis–Hillman (BH) acetates, involving three steps (reactions), (1) mono alkylation of 2-nitroarylacetonitriles with BH-acetates, (2) reduction of nitro group into amino group using Fe/AcOH and (3) formation of two (five and six membered) rings, is presented. This methodology is successfully applied to the synthesis of bioactive alkaloid neocryptolepine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The Royal Society of Chemistry. |
| ID Code: | 130101 |
| Deposited On: | 05 Dec 2022 05:54 |
| Last Modified: | 05 Dec 2022 05:54 |
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