Bhattacharya, Prabuddha ; Basak, Amit ; Campbell, Adam ; Alabugin, Igor V. (2018) Photochemical Activation of Enediyne Warheads: A Potential Tool for Targeted Antitumor Therapy Molecular Pharmaceutics, 15 (3). pp. 768-797. ISSN 1543-8384
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Official URL: http://doi.org/10.1021/Acs.Molpharmaceut.7B00911
Related URL: http://dx.doi.org/10.1021/Acs.Molpharmaceut.7B00911
Abstract
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 130058 |
| Deposited On: | 02 Dec 2022 05:59 |
| Last Modified: | 05 Dec 2022 05:48 |
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