Photochemical Activation of Enediyne Warheads: A Potential Tool for Targeted Antitumor Therapy

Bhattacharya, Prabuddha ; Basak, Amit ; Campbell, Adam ; Alabugin, Igor V. (2018) Photochemical Activation of Enediyne Warheads: A Potential Tool for Targeted Antitumor Therapy Molecular Pharmaceutics, 15 (3). pp. 768-797. ISSN 1543-8384

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Official URL: http://doi.org/10.1021/Acs.Molpharmaceut.7B00911

Related URL: http://dx.doi.org/10.1021/Acs.Molpharmaceut.7B00911

Abstract

Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:130058
Deposited On:02 Dec 2022 05:59
Last Modified:05 Dec 2022 05:48

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