Recent advances in Garratt-Braverman cyclization: Mechanistic and synthetic explorations

Abstract

Garratt-Braverman cyclization has emerged as one of the simplest synthetic tool to construct two consecutive Csingle bondC bonds leading to the formation of various important structural scaffolds having significance in the field of therapeutics and material science. The strategic design of suitable precursor for this cycloaromatization reaction involves the deep understanding of reaction pathways involving diradicals and ions. On the other hand, the reaction offers an unprecedented mechanistic paradox for the chemists to solve. This report aims at outlining the recent mechanistic and synthetic developments with special emphasis on the research outcomes from our laboratory.