Ghosh, Debaki ; Pal, Paramita ; Basak, Amit (2015) Sonogashira coupling and Garratt–Braverman cyclization in tandem: formation of four C–C bonds leading to the synthesis of aryl dihydro isofurans and isoindoles Tetrahedron Letters, 56 (15). pp. 1964-1967. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/J.Tetlet.2015.02.093
Related URL: http://dx.doi.org/10.1016/J.Tetlet.2015.02.093
Abstract
In this Letter we report an interesting one pot synthesis of aryl dihydro isofurans and isoindoles, naturally occurring privileged skeletons, in excellent yields from easily accessible starting materials. The process involved carrying out three reactions in a tandem manner leading to 4 C–C bond formations, namely two Sonogashira couplings (2 × 1 C–C bond) followed by Garratt–Braverman Cyclization (2 C–C bond).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Sonogashira; Garratt–Braverman; Cyclization; Tandem; Isofurans; Isoindoles |
| ID Code: | 130001 |
| Deposited On: | 05 Dec 2022 05:39 |
| Last Modified: | 05 Dec 2022 05:39 |
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