Sudheesh, Karivachery V. ; Jayaram, Prasad S. ; Samanta, Animesh ; Bejoymohandas, Kochan S. ; Jayasree, Ramapurath S. ; Ajayaghosh, Ayyappanpillai (2018) Frontispiece: A Cyclometalated IrIII Complex as a Lysosome-Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells Chemistry - A European Journal, 24 (43). ISSN 09476539
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Official URL: http://doi.org/10.1002/chem.201884365
Related URL: http://dx.doi.org/10.1002/chem.201884365
Abstract
Organelle-targeted photosensitizers with luminescence properties are potential theranostic agents for simultaneous imaging and photodynamic therapy. Described herein is a cyclometalated IrIII complex, Ir-Bp-Ly, that exhibits high triplet quantum yield and singlet-oxygen-generation efficiency. The close-proximity energy levels between triplet energy states of Ir-Bp-Ly and molecular oxygen favors efficient singlet oxygen and reactive oxygen species (ROS) generation. The good lysosomal specificity of Ir-Bp-Ly leads to its increased efficacy as a photodynamic therapeutic and imaging agent.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 129959 |
| Deposited On: | 28 Nov 2022 11:31 |
| Last Modified: | 28 Nov 2022 11:31 |
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