Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids

Goswami, Tridib K. ; Gadadhar, Sudarshan ; Gole, Bappaditya ; Karande, Anjali A. ; Chakravarty, Akhil R. (2013) Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids European Journal of Medicinal Chemistry, 63 . pp. 800-810. ISSN 02235234

Full text not available from this repository.

Official URL: http://doi.org/10.1016/j.ejmech.2013.03.026

Related URL: http://dx.doi.org/10.1016/j.ejmech.2013.03.026

Abstract

Copper(II) complexes [Cu(Fc-aa)(cur)] (1–3) of curcumin (Hcur) and N-ferrocenylmethyl-l-amino acids (Fc-aa), viz., ferrocenylmethyl-l-tyrosine (Fc-TyrH), ferrocenylmethyl-l-tryptophan (Fc-TrpH) and ferrocenylmethyl-l-methionine (Fc-MetH), were prepared and characterized. The DNA photocleavage activity, photocytotoxicity and cellular localization in HeLa and MCF-7 cancer cells of these complexes were studied. Acetylacetonate (acac) complexes [Cu(Fc-aa)(acac)] (4–6) were prepared and used as controls. The chemical nuclease inactive complexes showed efficient pUC19 DNA cleavage activity in visible light. Complexes 1–3 showed high photocytotoxicity with low dark toxicity thus giving remarkable photodynamic effect. FACScan analysis showed apoptosis of the cancer cells. Fluorescence microscopic studies revealed primarily cytosolic localization of the complexes.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Masson SAS
Keywords:Curcumin;Ferrocene;Copperl-Amino acids;Photocytotoxicity;Cellular uptake
ID Code:129852
Deposited On:21 Nov 2022 08:58
Last Modified:21 Nov 2022 08:58

Repository Staff Only: item control page