Sofi, Firdoos Ahmad ; Sharma, Rohit ; Chakraborti, Asit K. ; Bharatam, Prasad V. (2019) Tandem Oxidative Cyclocondensation towards 2,3-Disubstituted Quinazolinones in the Presence of [Bmim][BF4 ] and Iodine European Journal of Organic Chemistry, 2019 (34). pp. 5887-5893. ISSN 1434193X
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Official URL: http://doi.org/10.1002/ejoc.201900969
Related URL: http://dx.doi.org/10.1002/ejoc.201900969
Abstract
The metal-free synthesis of 2-aryl-3-arylmethylquinazolin-4(3H)-one is achieved through ionic liquid mediated and I2-promoted tandem oxidative cyclocondensation of isatoic anhydrides with arylmethylamines as the common precursor for the 2-aryl and 3-arylmethyl moieties. Radical quenching experiments suggest a non-radical mechanistic pathway and the operation under anaerobic condition confirms the essential role of I2 as the oxidant. Metal-free synthesis, reduced reaction times to afford higher product yields, recyclability of the IL used as the reaction medium, and the feasibility of gram scale operation are some advantages.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc |
| ID Code: | 129430 |
| Deposited On: | 16 Nov 2022 08:40 |
| Last Modified: | 16 Nov 2022 08:40 |
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