Bhagat, Shweta ; Arfeen, Minhajul ; Adane, Legesse ; Singh, Savita ; Singh, Prati Pal ; Chakraborti, Asit K. ; Bharatam, Prasad V. (2017) Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies European Journal of Medicinal Chemistry, 135 . pp. 339-348. ISSN 02235234
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Official URL: http://doi.org/10.1016/j.ejmech.2017.04.022
Related URL: http://dx.doi.org/10.1016/j.ejmech.2017.04.022
Abstract
Guanylthiourea (GTU) derivatives were identified as possible anti-malarial agents, recently, using in vitro studies on Plasmodium falciparum. This article gives an account of the in vivo anti-malarial activity of GTU derivatives against experimental rodent malaria. A total of 20 synthesized GTU derivatives were evaluated for in vivo antimalarial activity, out of which six showed encouraging results; one compound appeared to have curative potential. Molecular docking and molecular dynamics analysis were carried out to understand the molecular level interactions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V |
| Keywords: | Anti-malarials;Guanylthiourea;PfDHFR;Molecular dockingIn vivo testing;Curative agent |
| ID Code: | 129369 |
| Deposited On: | 16 Nov 2022 04:58 |
| Last Modified: | 16 Nov 2022 04:58 |
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