Brunner, Hermine I. ; Holland, Michael J. ; Beresford, Michael W. ; Ardoin, Stacy P. ; Appenzeller, Simone ; Silva, Clovis A. ; Flores, Francisco ; Goilav, Beatrice ; Avar Aydin, Pinar Ozge ; Wenderfer, Scott E. ; Levy, Deborah M. ; Ravelli, Angelo ; Khubchandani, Raju ; Avcin, Tadej ; Klein‐Gitelman, Marisa S. ; Ruperto, Nicolino ; Feldman, Brian M. ; Ying, Jun ; Battagliotti, Cristina ; Brusco, Maria Isabel ; Cuttica, Rubén ; De Cunto, Carmen ; Espada, Graciela ; Farfan, Maximiliano ; Garay, Stella ; Marcantoni, Maria ; Marcela, Alvarez ; Meiorin, Silvia ; Rama, Maria Elena ; Russo, Ricardo ; Torre Walsh, Carolina ; Zamparo, Celso ; Adib, Navid ; Akikusa, Jonathan ; Boros, Christina ; Lee, Senq J. ; Mckay, Damien ; Piper, Susan ; Joos, Rik ; Bica, Blanca ; Campos, Leonardo ; Cavalcanti, André ; do Prado, Rogerio ; Donner‐Maliki, Amanda ; Fernandes, Taciana ; Fonseca, Adriana ; Gasparello de Almeida, Rozana ; Guariento, Andressa ; Gusman, Catherine ; Jusan Fiorot, Fernanda ; Knupp Oliveira, Sheila ; Len, Claudio ; Arruda Campos, Lucia M. ; Machado, Sandra ; Marques, Luciana ; Martins de Carvalho, Luciana ; Moulin, Rodrigo ; Pedroso, Soraya ; Pileggi, Gecilmara ; Romanelli, Paulo Roberto S. ; Saad‐Magalhaes, Claudia ; Sakamoto, Ana ; Santos, Maria Carolina ; Silva, Marco Felipe ; Spelling, Paulo ; Sztajnbok, Slavio ; Terreri, Maria ; Cabral, David ; Chédeville, Gaëlle ; Ellsworth, Janet ; Huber, Adam ; Tucker, Lori ; Houghton, Kristin ; Borzutzky, Arturo ; Ladino, Mabel ; Norambuena, Ximena ; Eraso, Ruth ; Mosquera, Angela ; Velasquez, Monica ; Harjacek, Miroslav ; Jelusic, Marija ; Coto Hermosilla, Cecilia ; Dolezalova, Pavla ; Nielsen, Susan ; Tineo, Carmen ; Alegria, Mauricio ; Dressler, Frank ; Foell, Dirk ; Ganser, Gerd ; Hinze, Claas ; Hufnagel, Markus ; Lutz, Thomas ; Trauzeddel, Ralf ; Boiu, Sorina ; Trachana, Maria ; Tsitsami, Elena ; Cifuentes, Mayra ; Orbán, Ilonka ; Aggarwal, Amita ; Sawhney, Sujata ; Butbul Aviel, Yonatan ; Cimaz, Rolando ; Maggio, Maria Cristina ; Rumba‐Rozenfelde, Ingrid ; Hashad, Soad ; Lim, Sern Chin ; Abud, Carlos ; Burgos‐Vargas, Ruben ; Carreño‐Manjarrez, Roberto ; Enciso Pelaez, Sandra ; Hernandez‐Huirache, Hayde ; Maldonado Velázquez, Rocio ; Orozco, Javier ; Rodriguez‐Lozano, Ana Luisa ; Rojas Pacheco, Omar Ernesto ; Suárez Larios, Luz Maria ; Vega, Gabriel ; Ramírez Miramontes, Julia Verónica ; Ruíz Lopez, Ivon Karina ; Kamphuis, Sylvia ; Schonenberg‐Meinema, Dieneke ; Concannon, Anthony ; Yan, Jaqueline ; Jarquin Jaime, Martha ; Al Abrawi, Safiya ; Vega, Cynthia ; Lopez‐Benitez, Jorge ; Ibáñez Estrella, Amparo ; Miraval, Tatiana ; Dans, Leonia ; Kimseng, Karen Joy ; Opoka‐Winiarska, Violetta ; Rutkowska‐Sak, Lidia ; Smolewska, Elzbieta ; Conde, Marta ; Guedes, Margarida ; del Valle, Enid ; Quintero‐Del Rio, Ana ; Ailioaie, Constantin ; Sparchez, Mihaela ; Alekseeva, Ekaterina ; Keltsev, Vladimir ; Al‐Mayouf, Sulaiman ; Asiri, Abdurhman ; Suwairi, Wafaa ; Susic, Gordana ; Vijatov‐Djuric, Gordana ; Ang, Elizabeth ; Arkachaisri, Thaschawee ; Boteanu, Alina‐Lucica ; Lopez‐Robledillo, Juan Carlos ; Medrano San Ildefonso, Marta ; Modesto, Consuelo ; Calvo, Inmaculada ; Sotoca‐Fernandez, Jorge ; Bolt, Isabel ; Vilaiyuk, Soamarat ; Al‐Abadi, Eslam ; Baildam, Eileen ; Fotis, Lampros ; Pain, Clare ; Pilkington, Clarissa ; Abulaban, Khalid ; Barbar‐Smiley, Fatima ; Binstadt, Bryce ; Bohnsack, John ; Boneparth, Alexis ; Brown, Diane ; Chira, Peter ; Cron, Randy ; Dedeoglu, Fatma ; Eberhard, Anne ; Gedalia, Abraham ; Grom, Alexei ; Henrickson, Michael ; Hom, Christine ; Huggins, Jennifer ; Jerath, Rita ; Jones, Jordan ; Jung, Lawrence ; Kingsbury, Daniel ; Lai, Jamie ; Lovell, Daniel ; Nanda, Kabita ; Nocton, James ; Olson, Judyann ; O’Neil, Kathleen ; Onel, Karen ; Punaro, Lynn ; Reiff, Andreas ; Rouster‐Stevens, Kelly ; Ruth, Natasha ; Schikler, Ken ; Murphy Schmidt, Kara ; Schulert, Grant ; Shaham, Bracha ; Singer, Nora ; Smith, Judith ; Sundel, Robert ; Syverson, Grant ; Vega‐Fernandez, Patricia ; Vehe, Richard ; Wagner‐Weiner, Linda ; Cameto, Juan ; Jurado, Rosario ; Maldonado, Irama (2019) American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood‐Onset Systemic Lupus Erythematosus Arthritis Care & Research, 71 (5). pp. 579-590. ISSN 2151-464X
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Official URL: http://doi.org/10.1002/acr.23834
Related URL: http://dx.doi.org/10.1002/acr.23834
Abstract
Objective: To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIc SLE ). Methods: Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIc SLE and rate a total of 433 unique patient profiles for the presence/absence of CRIc SLE . Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE-CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC]; range 0-1). Results: During an international consensus conference, unanimous agreement on a definition of CRIc SLE was achieved; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE-CRVs. After transformation to a range of 0-100, a CHILI score of ≥54 had outstanding accuracy for identifying CRIc SLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC ≥0.92, sensitivity ≥93.1%, and specificity ≥73.4%). Conclusion: The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| Keywords: | lupus, childhood-onset SLE, SLE, pediatric SLE, juvenile SLE, improvement, criteria, children, cSLE |
| ID Code: | 129324 |
| Deposited On: | 22 Nov 2022 11:43 |
| Last Modified: | 22 Nov 2022 11:43 |
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