Chadha, Renu ; Jain, D. V. S. ; Aggarwal, Amit ; Singh, Surjit ; Thakur, Deepika (2007) Binding constants of inclusion complexes of nitroimidazoles with β-cyclodextrins in the absence and presence of PVP Thermochimica Acta, 459 (1-2). pp. 111-115. ISSN 0040-6031
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00406...
Related URL: http://dx.doi.org/10.1016/j.tca.2007.04.016
Abstract
Thermodynamics of complexation of 5-nitroimidazoles with β -cyclodextrin and its methylated and hydroxypropyl derivatives in water and in 0.25% polyvinylpyrrolidone are determined by solution calorimetry. A 1:1 stoichiometry was established. The equilibrium constant (K) for all the nitroimidazoles fall in the range 1000-1900 M-1 suitable for use of cyclodextrins as drug carriers. The complexation ability is significantly enhanced by methylation of the β-cyclodextrin. The stability constant increased in the order metronidazole < ornidazole < tinidazole < secnidazole. The presence of polyvinylpyrrolidone enhances the stability constants.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cyclodextrin; Calorimetry; Nitroimidazole; Thermodynamic Parameters; Polyvinylpyrrolidone |
| ID Code: | 12925 |
| Deposited On: | 11 Nov 2010 08:25 |
| Last Modified: | 03 Jun 2011 06:44 |
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