Nair, Vijay ; Mohanan, Kishor ; Suja, Tachapully ; Biju, Akkattu (2007) Stereoselective Synthesis of 3,4-trans-Disubstituted γ-Lactams by Cerium(IV) Ammonium Nitrate Mediated Radical Cyclization of Cinnamamides Synthesis, 2007 (8). pp. 1179-1184. ISSN 0039-7881
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Official URL: http://doi.org/10.1055/s-2007-965981
Related URL: http://dx.doi.org/10.1055/s-2007-965981
Abstract
A facile synthesis of 3,4-trans-disubstituted γ-lactams was developed, consisting of the radical cyclization of cinnamamides mediated by cerium(IV) ammonium nitrate. The single-electron-transfer (SET) reaction of the methoxystyrenyl moiety mediated by cerium(IV) ammonium nitrate gives rise to a cation radical, whose cyclization followed by reaction with oxygen and methanol generates 3,4-trans-disubstituted γ-lactams.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Georg Thieme Verlag KG |
| Keywords: | cerium(IV) ammonium nitrate, intramolecular cyclization, cinnamamides, single electron transfer, γ-lactams |
| ID Code: | 128744 |
| Deposited On: | 03 Nov 2022 06:57 |
| Last Modified: | 03 Nov 2022 06:57 |
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