Padmanaban, Mohan ; Biju, Akkattu T. ; Glorius, Frank (2011) N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aromatic Aldehydes with Activated Alkyl Halides Organic Letters, 13 (1). pp. 98-101. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol102626p
Related URL: http://dx.doi.org/10.1021/ol102626p
Abstract
N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 128730 |
| Deposited On: | 03 Nov 2022 06:56 |
| Last Modified: | 03 Nov 2022 06:56 |
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