Kaicharla, Trinadh ; Yetra, Santhivardhana Reddy ; Roy, Tony ; Biju, Akkattu T. (2013) Engaging isatins in solvent-free, sterically congested Passerini reaction Green Chemistry, 15 (6). p. 1608. ISSN 1463-9262
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Official URL: http://doi.org/10.1039/C3GC40454D
Related URL: http://dx.doi.org/10.1039/C3GC40454D
Abstract
A facile, atom-economic and environmentally-benign protocol for the synthesis of biologically important oxindole derivatives in high yields has been demonstrated by employing isatins as carbonyl compound surrogates in a Passerini reaction carried out under solvent-free conditions. Moreover, electron-deficient phenols can also be used as the acid component in this reaction. In addition, the synthetic utility of the present methodology was examined by the one-pot synthesis of oxindoles with a free –OH group at the benzylic position.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 128697 |
| Deposited On: | 03 Nov 2022 06:53 |
| Last Modified: | 03 Nov 2022 06:53 |
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