Practical Synthesis of Phthalimides and Benzamides by a Multicomponent Reaction Involving Arynes, Isocyanides, and CO2/H2O

Kaicharla, Trinadh ; Thangaraj, Manikandan ; Biju, Akkattu T. (2014) Practical Synthesis of Phthalimides and Benzamides by a Multicomponent Reaction Involving Arynes, Isocyanides, and CO2/H2O Organic Letters, 16 (6). pp. 1728-1731. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol500403x

Related URL: http://dx.doi.org/10.1021/ol500403x

Abstract

Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:128689
Deposited On:03 Nov 2022 06:53
Last Modified:03 Nov 2022 06:53

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