Kaicharla, Trinadh ; Biju, Akkattu T. (2015) Transition-Metal-Free Synthesis of Benzo-Fused Five- and Six-Membered Heterocycles Employing Arynes Green Synthetic Approaches for Biologically Relevant Heterocycles . pp. 45-76.
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Official URL: http://doi.org/10.1016/B978-0-12-800070-0.00003-7
Related URL: http://dx.doi.org/10.1016/B978-0-12-800070-0.00003-7
Abstract
A comprehensive overview of the synthesis of various benzo-fused five- and six-membered heterocyclic compounds utilizing a transition-metal-free approach employing arynes is the focal theme of this chapter. The synthesis of these heterocycles has been achieved under green and operationally simple procedures using a mild method for the generation of arynes by the fluoride-induced 1,2-elimination of 2-(trimethylsilyl)aryl triflates developed by Kobayashi and coworkers in 1983. Consequently, arynes have been employed for the construction of multisubstituted arenes of structural diversity and complexity. The versatile transition-metal-free applications of arynes include cycloaddition reactions, insertion reactions, and multicomponent reactions for the construction of various heterocycles.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Inc. |
| Keywords: | Arynes, Cycloaddition reactions, Heterocycles, Insertion reactions, Multicomponent reactions, Transition-metal-free reaction |
| ID Code: | 128683 |
| Deposited On: | 03 Nov 2022 06:53 |
| Last Modified: | 11 Nov 2022 05:02 |
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