Transition-Metal-Free Synthesis of Benzo-Fused Five- and Six-Membered Heterocycles Employing Arynes

Kaicharla, Trinadh ; Biju, Akkattu T. (2015) Transition-Metal-Free Synthesis of Benzo-Fused Five- and Six-Membered Heterocycles Employing Arynes Green Synthetic Approaches for Biologically Relevant Heterocycles . pp. 45-76.

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Official URL: http://doi.org/10.1016/B978-0-12-800070-0.00003-7

Related URL: http://dx.doi.org/10.1016/B978-0-12-800070-0.00003-7

Abstract

A comprehensive overview of the synthesis of various benzo-fused five- and six-membered heterocyclic compounds utilizing a transition-metal-free approach employing arynes is the focal theme of this chapter. The synthesis of these heterocycles has been achieved under green and operationally simple procedures using a mild method for the generation of arynes by the fluoride-induced 1,2-elimination of 2-(trimethylsilyl)aryl triflates developed by Kobayashi and coworkers in 1983. Consequently, arynes have been employed for the construction of multisubstituted arenes of structural diversity and complexity. The versatile transition-metal-free applications of arynes include cycloaddition reactions, insertion reactions, and multicomponent reactions for the construction of various heterocycles.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Inc.
Keywords:Arynes, Cycloaddition reactions, Heterocycles, Insertion reactions, Multicomponent reactions, Transition-metal-free reaction
ID Code:128683
Deposited On:03 Nov 2022 06:53
Last Modified:11 Nov 2022 05:02

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