N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction

Mukherjee, Subrata ; Mondal, Santigopal ; Patra, Atanu ; Gonnade, Rajesh G. ; Biju, Akkattu T. (2015) N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction Chemical Communications, 51 (46). pp. 9559-9562. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/C5CC02960K

Related URL: http://dx.doi.org/10.1039/C5CC02960K

Abstract

NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of β-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry
ID Code:128675
Deposited On:03 Nov 2022 06:51
Last Modified:03 Nov 2022 06:51

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