Mondal, Santigopal ; Ghosh, Arghya ; Mukherjee, Subrata ; Biju, Akkattu T. (2018) N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Spiro-glutarimides via α,β-Unsaturated Acylazoliums Organic Letters, 20 (15). pp. 4499-4503. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.8b01799
Related URL: http://dx.doi.org/10.1021/acs.orglett.8b01799
Abstract
NHC-catalyzed enantioselective [3 + 3] spiro-annulation of α,β-unsaturated aldehydes with cyclic β-ketoamides allowing the preparation of synthetically and biologically important spiro-glutarimide derivatives has been reported. The interception of the ketoamides with catalytically generated chiral α,β-unsaturated acylazoliums proceeds in a Michael addition-intramolecular amidation pathway to deliver the spirocyclic products with good yield, diastereoselectivity, and enantioselectivity.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society |
ID Code: | 128621 |
Deposited On: | 03 Nov 2022 06:49 |
Last Modified: | 03 Nov 2022 06:49 |
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