Bhattacharjee, Subrata ; Guin, Avishek ; Gaykar, Rahul N. ; Biju, Akkattu T. (2019) Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-Iodobenzyl Alcohols Organic Letters, 21 (11). pp. 4383-4387. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.9b01621
Related URL: http://dx.doi.org/10.1021/acs.orglett.9b01621
Abstract
The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal-free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcohols in moderate to good yields with good functional group compatibility. Moreover, KBr and KCl could be used as the nucleophilic trigger in this aryne multicomponent coupling (MCC) and N-methylisatin and CO2 could be used as the electrophilic third components.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 128606 |
| Deposited On: | 03 Nov 2022 06:45 |
| Last Modified: | 03 Nov 2022 06:45 |
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