Das, Tamal Kanti ; Biju, Akkattu T. (2020) N-Heterocyclic Carbene (NHC)-Catalyzed Transformations for the Synthesis of Heterocycles Progress in Heterocyclic Chemistry, 31 . pp. 1-82. ISSN 09596380
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Official URL: http://doi.org/10.1016/B978-0-12-819962-6.00001-4
Related URL: http://dx.doi.org/10.1016/B978-0-12-819962-6.00001-4
Abstract
N-heterocyclic carbene (NHC)-based organocatalysis has been widely used for unconventional access to various target molecules. The use of chiral NHCs in the process results in the enantioselective synthesis of various heterocycles. The underlying principle of many of the NHC-catalyzed reactions is the remarkable ability of NHCs to reverse the normal mode of reactivity of aldehydes (umpolung). NHCs can catalyze transformations proceeding via the umpolung or nonumpolung mode for the synthesis of various functionalized molecules. The recent advances in the application of NHCs for the synthesis of various heterocyclic compounds are highlighted in this chapter.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd. |
| Keywords: | Aldimine umpolung, Benzoin reaction, Breslow intermediates, Enantioselective synthesis, Heterocyclic synthesis, aldehyde umpolung, N-Heterocyclic carbene, Stetter reaction |
| ID Code: | 128605 |
| Deposited On: | 03 Nov 2022 06:45 |
| Last Modified: | 03 Nov 2022 06:45 |
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