Bhattacharjee, Subrata ; Guin, Avishek ; Gaykar, Rahul N. ; Biju, Akkattu T. (2020) Thiophenols as Protic Nucleophilic Triggers in Aryne Three-Component Coupling Organic Letters, 22 (22). pp. 9097-9101. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.0c03494
Related URL: http://dx.doi.org/10.1021/acs.orglett.0c03494
Abstract
The synthetic potential of thiophenols as a protic nucleophilic trigger in the transition-metal-free and Grignard-reagent-free three-component coupling involving arynes is demonstrated. Employing aldehydes as the third component, the reaction allowed the mild and broad scope synthesis of 2-arylthio benzyl alcohol derivatives in good yields. Moreover, selenophenol could be used as the nucleophilic trigger, and activated ketones could be used as the third component in this reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 128593 |
| Deposited On: | 03 Nov 2022 06:43 |
| Last Modified: | 03 Nov 2022 06:43 |
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