Ghosh, Arghya ; Barik, Shilpa ; Shee, Sayan ; Biju, Akkattu T. (2021) Enantioselective synthesis of tetra-substituted tetralines and tetrahydro-indolizines by NHC-catalyzed azolium–enolate cascade Chemical Communications, 57 (63). pp. 7794-7797. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/D1CC03165A
Related URL: http://dx.doi.org/10.1039/D1CC03165A
Abstract
NHC-catalyzed cascade reaction of enals with suitably substituted β-(hetero)aryl enones allowing the enantioselective synthesis of tetra-substituted tetralines and tetrahydro indolizines is presented. The catalytically generated chiral α,β-unsaturated acylazoliums from enals under oxidative conditions reacted in a Michael–Michael-lactonization sequence to form the tricyclic δ-lactone products bearing four contiguous stereocentres.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 128584 |
| Deposited On: | 03 Nov 2022 06:37 |
| Last Modified: | 03 Nov 2022 06:37 |
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