Polarimetry-based method to extract geometry-independent metrics of tissue anisotropy

Wallenburg, Marika A. ; Wood, Michael F. G. ; Ghosh, Nirmalya ; Vitkin, I. Alex (2010) Polarimetry-based method to extract geometry-independent metrics of tissue anisotropy Optics Letters, 35 (15). p. 2570. ISSN 0146-9592

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Official URL: http://doi.org/10.1364/OL.35.002570

Related URL: http://dx.doi.org/10.1364/OL.35.002570

Abstract

Recently, we have used polarimetry as a method for assessing the linear retardance of infarcted myocardium. While linear retardance reflects tissue anisotropy, experimental geometry has a confounding effect due to dependence of the linear retardance on the orientation of the sample with respect to the probing beam. Here, polarimetry imaging of an 8mm diameter birefringent polystyrene sphere of known anisotropy axis was used to test a dual-projection method by which the anisotropy axis and its true magnitude can be reconstructed, thus eliminating the confounding effect of anisotropy axis orientation. Feasibility is demonstrated in ex-vivo tissue imaging.

Item Type:Article
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ID Code:127948
Deposited On:14 Oct 2022 11:33
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