Srinivasan, Bharath ; Balaram, Hemalatha (2007) ISN1 Nucleotidases and HAD Superfamily Protein Fold: In silico Sequence and Structure Analysis In Silico Biology, 7 (2). pp. 187-193. ISSN 1386-6338
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Official URL: http://iospress.metapress.com/index/3218404x262576...
Abstract
cN-II class of 5' purine nucleotidases exhibit specificity for IMP/GMP and belong to the HAD (haloacid dehalogenase) superfamily of hydrolases. The recently identified ISN1 class of IMP specific 5'-nucleotidases occurring in yeast, fungi and certain Plasmodia lack sequence homology with the cN-II class of enzymes. We show from analysis of motif and fold conservation that ISN1s also belong to the HAD superfamily. This identification adds a new novel member to this superfamily.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bioinformation Systems e.V.. |
| Keywords: | Purine Nucleotidase; ISN1 Nucleotidase; HAD Superfamily; Distant Homology Modeling; Phylogenetic Analysis |
| ID Code: | 1273 |
| Deposited On: | 04 Oct 2010 07:57 |
| Last Modified: | 08 Jan 2011 03:38 |
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