Effect of dietary supplementation of vitamin E in partial inhibition of Russell's viper venom phospholipase A2 induced hepatocellular and microsomal membrane damage in rats

Mukherjee, A K ; Maity, C R (1997) Effect of dietary supplementation of vitamin E in partial inhibition of Russell's viper venom phospholipase A2 induced hepatocellular and microsomal membrane damage in rats Acta Physiologica Hungarica, 85 (4). pp. 367-374. ISSN Print ISSN 0231-424X Online ISSN 1588-2683

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Abstract

The current investigation furnishes a good correlation between the alpha-tocopherol content of the liver and microsomes and corresponding inhibition of Russell's viper venom phospholipase A2 inflicted damage to them. Dietary supplementation of d1-alpha-tocopherol at a concentration of 100 mg and 200 mg per kg of diet displayed less damage caused by venom phospholipase A2 in sharp contrast to the vitamin E deficient rats. alpha-tocopherol due presumably to the formation of complexes with the phospholipid hydrolysis products of the membranes, plays a significant role in membrane stabilization.

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