Mukherjee, Ashis K. (2008) Phospholipase A2-interacting weak neurotoxins from venom of monocled cobra Naja kaouthia display cell-specific cytotoxicity Toxicon, 51 (8). pp. 1538-1543. ISSN 00410101
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.toxicon.2008.03.014
Related URL: http://dx.doi.org/10.1016/j.toxicon.2008.03.014
Abstract
The molecular weights of two phospholipase A2 (PLA2)-interacting polypeptides (kaouthiotoxins (KTXs)—KTX-A and KTX-B) purified from the venom of monocled cobra Naja kaouthia, were estimated by mass spectrometry as 7722 and 7627 Da, respectively. Binary sequence alignment showed that both KTXs share substantial sequence homology with weak neurotoxins from cobra venom and they were devoid of any enzymatic activity. Their pI was determined at pH 8.1 showing basic nature of these proteins. KTXs displayed cell-specific cytotoxicity on mammalian and insect cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd. |
| Keywords: | Cytotoxicity, Cobra venom, Monocled cobra, Naja kaouthia, Weak neurotoxin, Sf9 cell, VERO cell |
| ID Code: | 126889 |
| Deposited On: | 13 Oct 2022 08:08 |
| Last Modified: | 13 Oct 2022 08:08 |
Repository Staff Only: item control page
