Mukherjee, Ashis K. ; Chatterjee, Suvro ; Majumder, Syamantak ; Saikia, Debashree ; Thakur, Rupamoni ; Chatterjee, Anupam (2014) Characterization of a pro-angiogenic, novel peptide from Russell's viper (Daboia russelii russelii) venom Toxicon, 77 . pp. 26-31. ISSN 00410101
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Official URL: http://doi.org/10.1016/j.toxicon.2013.10.024
Related URL: http://dx.doi.org/10.1016/j.toxicon.2013.10.024
Abstract
Present report shows for the first time on the induction of in vitro angiogenesis by a 3.9 kDa novel peptide (RVVAP) purified from Russell's viper venom. Secondary structure of RVVAP is made up of 36.8% α-helix, 33.3% β pleated sheets and 29.9% turns. Optimum angiogenesis and significant elevation in endothelial migration were observed at 50 ng/ml of RVVAP treatment; above this concentration, progressive decrease in wound healing was noted. RVVAP (1.0 μg/ml) was non-cytotoxic to U87-MG, HeLa and HT-29 cells; however, increasing the RVVAP concentration above 500 ng/ml resulted in induction of chromosomal aberrations and delay in cell cycle kinetics of Chinese hamster ovary cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd. |
| Keywords: | Angiogenesis; Chromosomal aberration; Cytotoxicity; Russell's viper; Wound healing |
| ID Code: | 126826 |
| Deposited On: | 13 Oct 2022 07:02 |
| Last Modified: | 13 Oct 2022 07:02 |
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