Prasanth, Thumpati ; Chakraborti, Gargi ; Mandal, Tirtha ; Ravichandiran, Velayutham ; Dash, Jyotirmayee (2022) Cycloaddition of N-sulfonyl and N-sulfamoyl azides with alkynes in aqueous media for the selective synthesis of 1,2,3-triazoles Green Chemistry, 24 (2). pp. 911-915. ISSN 1463-9262
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Official URL: http://doi.org/10.1039/D1GC03340A
Related URL: http://dx.doi.org/10.1039/D1GC03340A
Abstract
The cycloaddition of N-sulfonyl and N-sulfamoyl azides with terminal alkynes generally produces amide derivatives via ketenimine intermediates. We herein delineate a Cu(I) catalyzed method using a prolinamide ligand that selectively generates N-sulfonyl and sulfamoyltriazoles in aqueous media by inhibiting the cleavage of the N1–N2 bond of 5-cuprated triazole intermediates. The present method is mild and tolerant to air, moisture and a wide range of functional groups, thereby providing easy access to a variety of triazole products.
Item Type: | Article |
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Source: | Copyright of this article belongs to Royal Society of Chemistry. |
ID Code: | 126698 |
Deposited On: | 17 Oct 2022 05:35 |
Last Modified: | 17 Oct 2022 05:35 |
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