Saha, Puja ; Kumar, Y. Pavan ; Das, Tania ; Müller, Diana ; Bessi, Irene ; Schwalbe, Harald ; Dash, Jyotirmayee (2019) G-Quadruplex-Specific Cell-Permeable Guanosine–Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the c-MYC Gene Bioconjugate Chemistry, 30 (12). pp. 3038-3045. ISSN 1043-1802
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Official URL: http://doi.org/10.1021/acs.bioconjchem.9b00655
Related URL: http://dx.doi.org/10.1021/acs.bioconjchem.9b00655
Abstract
We herein report a cell-membrane permeable molecular probe ADG, prepared by conjugating guanosine with anthracene selectively interacts with c-MYC quadruplex over other promoter and telomeric quadruplexes as well as duplex DNA. NMR spectroscopy suggests that ADG interacts with terminal G-quartets as well as with the nearby G-rich tract (G13-G14-G15 and G8-G9-G10) of c-MYC quadruplex. In vitro cellular studies indicate that ADG represses c-MYC expression by stabilizing its promoter G-quadruplex and alters c-MYC related cellular events. ADG suppresses hTERT and BCL2 gene expressions, inhibits elongation of telomere length and activates apoptotic cascades in cancer cells.
Item Type: | Article |
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Source: | Copyright of this article belongs to ResearchGate GmbH. |
ID Code: | 126659 |
Deposited On: | 17 Oct 2022 05:42 |
Last Modified: | 09 Nov 2022 06:35 |
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