Maji, Samir Kumar ; Haldar, Debasish ; Drew, Michael G.B ; Banerjee, Arijit ; Das, Apurba Kumar ; Banerjee, Arindam (2004) Self-assembly of β-turn forming synthetic tripeptides into supramolecular β-sheets and amyloid-like fibrils in the solid state Tetrahedron, 60 (14). pp. 3251-3259. ISSN 00404020
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Official URL: http://doi.org/10.1016/j.tet.2004.02.019
Related URL: http://dx.doi.org/10.1016/j.tet.2004.02.019
Abstract
We have described here the self-assembling properties of the synthetic tripeptides Boc-Ala(1)-Aib(2)-Val(3)-OMe 1, Boc-Ala(1)-Aib(2)-Ile(3)-OMe 2 and Boc-Ala(1)-Gly(2)-Val(3)-OMe 3 (Aib=α-amino isobutyric acid, β-Ala=β-alanine) which have distorted β-turn conformations in their respective crystals. These turn-forming tripeptides self-assemble to form supramolecular β-sheet structures through intermolecular hydrogen bonding and other noncovalent interactions. The scanning electron micrographs of these peptides revealed that these compounds form amyloid-like fibrils, the causative factor for many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Prion-related encephalopathies.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V |
| Keywords: | Amyloid-like fibril;β-Turn;Supramolecular β-sheet;Self-assembling peptides |
| ID Code: | 126606 |
| Deposited On: | 31 Oct 2022 04:25 |
| Last Modified: | 31 Oct 2022 04:25 |
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