A DNA-Inspired Synthetic Ion Channel Based on G–C Base Pairing

Das, Rabindra Nath ; Kumar, Y. Pavan ; Schütte, Ole Mathis ; Steinem, Claudia ; Dash, Jyotirmayee (2015) A DNA-Inspired Synthetic Ion Channel Based on G–C Base Pairing Journal of the American Chemical Society, 137 (1). pp. 34-37. ISSN 0002-7863

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Official URL: http://doi.org/10.1021/ja510470b

Related URL: http://dx.doi.org/10.1021/ja510470b

Abstract

A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a modular one-pot azide-alkyne cycloaddition. Single channel analysis showed that this dinucleoside predominantly forms large channels with 2.9 nS conductance for the transport of potassium ions across a phospholipid bilayer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and circular dichroism (CD) spectroscopy studies reveal that this dinucleoside can spontaneously associate through Watson-Crick canonical H-bonding and π-π stacking to form stable supramolecular nanostructures. Most importantly, the ion channel activity of this G-C dinucleoside can be inhibited using the nucleobase cytosine.

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ID Code:126585
Deposited On:17 Oct 2022 05:47
Last Modified:17 Oct 2022 05:47

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