Das, Rabindra Nath ; Kumar, Y. Pavan ; Schütte, Ole Mathis ; Steinem, Claudia ; Dash, Jyotirmayee (2015) A DNA-Inspired Synthetic Ion Channel Based on G–C Base Pairing Journal of the American Chemical Society, 137 (1). pp. 34-37. ISSN 0002-7863
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Official URL: http://doi.org/10.1021/ja510470b
Related URL: http://dx.doi.org/10.1021/ja510470b
Abstract
A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a modular one-pot azide-alkyne cycloaddition. Single channel analysis showed that this dinucleoside predominantly forms large channels with 2.9 nS conductance for the transport of potassium ions across a phospholipid bilayer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and circular dichroism (CD) spectroscopy studies reveal that this dinucleoside can spontaneously associate through Watson-Crick canonical H-bonding and π-π stacking to form stable supramolecular nanostructures. Most importantly, the ion channel activity of this G-C dinucleoside can be inhibited using the nucleobase cytosine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to ResearchGate GmbH. |
| ID Code: | 126585 |
| Deposited On: | 17 Oct 2022 05:47 |
| Last Modified: | 17 Oct 2022 05:47 |
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