Kumar, Y. Pavan ; Bhowmik, Sudipta ; Das, Rabindra Nath ; Bessi, Irene ; Paladhi, Sushovan ; Ghosh, Rita ; Schwalbe, Harald ; Dash, Jyotirmayee (2013) A Fluorescent Guanosine Dinucleoside as a Selective Switch-On Sensor forc-mycG-Quadruplex DNA with Potent Anticancer Activities Chemistry - A European Journal, 19 (35). pp. 11502-11506. ISSN 0947-6539
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Official URL: http://doi.org/10.1002/chem.201302107
Related URL: http://dx.doi.org/10.1002/chem.201302107
Abstract
A novel fluorescent C2-symmetric guanosine-based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| ID Code: | 126573 |
| Deposited On: | 17 Oct 2022 05:48 |
| Last Modified: | 17 Oct 2022 05:48 |
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