Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

Colon, Aude ; Hoffman, Thomas J. ; Gebauer, Julian ; Dash, Jyotirmayee ; Rigby, James H. ; Arseniyadis, Stellios ; Cossy, Janine (2012) Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F Chemical Communications, 48 (85). p. 10508. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/C2CC35721F

Related URL: http://dx.doi.org/10.1039/C2CC35721F

Abstract

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

Item Type:Article
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ID Code:126563
Deposited On:17 Oct 2022 05:49
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