Dash, Jyotirmayee ; Melillo, Bruno ; Arseniyadis, Stellios ; Cossy, Janine (2011) A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles Tetrahedron Letters, 52 (17). pp. 2246-2249. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2011.01.027
Related URL: http://dx.doi.org/10.1016/j.tetlet.2011.01.027
Abstract
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cross-metathesis; Natural products; Alkene; Thiazole; Pyridine |
| ID Code: | 126550 |
| Deposited On: | 17 Oct 2022 05:50 |
| Last Modified: | 17 Oct 2022 05:50 |
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