Shukla, Arun K. ; Sun, Jin-Peng ; Lefkowitz, Robert J. (2008) Crystallizing Thinking about the β2-Adrenergic Receptor Molecular Pharmacology, 73 (5). pp. 1333-1338. ISSN 0026-895X
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Official URL: http://doi.org/10.1124/mol.108.045849
Related URL: http://dx.doi.org/10.1124/mol.108.045849
Abstract
Two recently determined crystal structures of the human beta2-adrenergic receptor (beta2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The beta2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Pharmacology and Experimental Therapeutics |
| ID Code: | 126522 |
| Deposited On: | 13 Oct 2022 06:47 |
| Last Modified: | 13 Oct 2022 06:47 |
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