Ranjan, Ravi ; Gupta, Pragya ; Shukla, Arun K. (2016) GPCR Signaling: β-arrestins Kiss and Remember Current Biology, 26 (7). R285-R288. ISSN 09609822
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Official URL: http://doi.org/10.1016/j.cub.2016.02.056
Related URL: http://dx.doi.org/10.1016/j.cub.2016.02.056
Abstract
β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd. |
| ID Code: | 126453 |
| Deposited On: | 13 Oct 2022 06:04 |
| Last Modified: | 13 Oct 2022 06:04 |
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