Chaturvedi, Madhu ; Maharana, Jagannath ; Shukla, Arun K. (2020) Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes Cell, 180 (6). pp. 1041-1043. ISSN 00928674
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Official URL: http://doi.org/10.1016/j.cell.2020.02.047
Related URL: http://dx.doi.org/10.1016/j.cell.2020.02.047
Abstract
β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Inc. |
| ID Code: | 126384 |
| Deposited On: | 13 Oct 2022 05:59 |
| Last Modified: | 13 Oct 2022 05:59 |
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