Maharana, Jagannath ; Sarma, Parishmita ; Shukla, Arun K. (2022) Scratching the itch with cryo-EM Nature Chemical Biology, 18 (3). pp. 242-243. ISSN 1552-4450
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Official URL: http://doi.org/10.1038/s41589-021-00959-4
Related URL: http://dx.doi.org/10.1038/s41589-021-00959-4
Abstract
The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Chemical Biology |
| Keywords: | MRGPRs, itch, structure, cryoEM, mast cell, DRG neuron |
| ID Code: | 126333 |
| Deposited On: | 13 Oct 2022 05:57 |
| Last Modified: | 13 Oct 2022 05:57 |
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