Bhansali, Shobhit ; Dutta, Pinaki ; Yadav, Mukesh Kumar ; Jain, Ashish ; Mudaliar, Sunder ; Hawkins, Meredith ; Kurpad, Anura V. ; Pahwa, Deepak ; Yadav, Ashok Kumar ; Sharma, Ratti Ram ; Jha, Vivekanand ; Marwaha, Neelam ; Bhansali, Shipra ; Bhansali, Anil (2017) Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity Diabetology & Metabolic Syndrome, 9 (1). ISSN 1758-5996
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Official URL: http://doi.org/10.1186/s13098-017-0248-7
Related URL: http://dx.doi.org/10.1186/s13098-017-0248-7
Abstract
Insulin resistance and insulin deficiency are the cardinal defects in the pathogenesis of type 2 diabetes mellitus (T2DM). Despite the plethora of anti-diabetic medications, drugs specifically targeting the β-cells are still desired. Stem cell therapy has emerged as a novel therapeutics strategy to target β-cells; however, their mechanism of action has not been well defined. This study aims to examine the efficacy and safety of autologous bone marrow-derived mononuclear cells (ABM-MNCs) transplantation in T2DM, and explores the mechanistic insights into stem cells action through metabolic studies.
Item Type: | Article |
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Source: | Copyright of this article belongs to BioMed Central Ltd |
Keywords: | T2DM, Stem cells, Autologous bone marrow-derived mononuclear cells |
ID Code: | 126294 |
Deposited On: | 13 Oct 2022 05:48 |
Last Modified: | 13 Oct 2022 05:48 |
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