One-Pot Synthesis of an Acid-Labile Amphiphilic Triblock Copolymer and its pH-Responsive Vesicular Assembly

Dan, Krishna ; Ghosh, Suhrit (2013) One-Pot Synthesis of an Acid-Labile Amphiphilic Triblock Copolymer and its pH-Responsive Vesicular Assembly Angewandte Chemie International Edition, 52 (28). pp. 7300-7305. ISSN 1433-7851

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Official URL: http://doi.org/10.1002/anie.201302722

Related URL: http://dx.doi.org/10.1002/anie.201302722

Abstract

An amphiphilic triblock copolymer segmented by an acid-labile β-thiopropionate linker was synthesized from a dithiol, a diacrylate, and an acrylate-terminated hydrophilic polymer in two steps in one pot. It showed spontaneous vesicular assembly, and the stimuli-responsive disassembly at mild acidic pH values resulted in sustained release of noncovalently encapsulated guest molecules.

Item Type:Article
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ID Code:126202
Deposited On:17 Oct 2022 11:40
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