Dwivedi, Ved Prakash ; Bhattacharya, Debapriya ; Singh, Mona ; Bhaskar, Ashima ; Kumar, Santosh ; Fatima, Samreen ; Sobia, Parveen ; Kaer, Luc Van ; Das, Gobardhan (2019) Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection Journal of Ethnopharmacology, 243 . p. 111634. ISSN 0378-8741
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Official URL: http://doi.org/10.1016/j.jep.2018.12.008
Related URL: http://dx.doi.org/10.1016/j.jep.2018.12.008
Abstract
Ethnopharmacological relevance The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) strains has severely hampered global efforts towards tuberculosis (TB) eradication. The internationally accepted therapy “Directly Observed Treatment Short-course (DOTS)” is lengthy, and incorporates risks for the generation of drug-resistant M.tb variants. Multiple and extremely drug-resistant (MDR and XDR) variants of TB are now widespread throughout the globe, and totally drug-resistant (TDR) strains have appeared. Therefore, new classes of antibiotics are urgently needed to combat these deadly organisms. Historically, garlic is known to kill mycobacterial strains, and its active compound, allicin, kills various microorganisms. Here we have shown that allicin not only reduced the bacterial burden in the lungs of mice infected with Mycobacterium tuberculosis (M.tb), but also induces strong anti-tubercular immunity.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 124497 |
Deposited On: | 22 Nov 2021 12:34 |
Last Modified: | 22 Nov 2021 12:34 |
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