Sreekanth, Vedagopuram ; Kar, Animesh ; Kumar, Sandeep ; Pal, Sanjay ; Yadav, Poonam ; Sharma, Yamini ; Komalla, Varsha ; Sharma, Harsh ; Shyam, Radhey ; Sharma, Ravi Datta ; Mukhopadhyay, Arnab ; Sengupta, Sagar ; Dasgupta, Ujjaini ; Bajaj, Avinash (2021) Bile Acid Tethered Docetaxel‐Based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes Angewandte Chemie International Edition, 60 (10). pp. 5394-5399. ISSN 1433-7851
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Official URL: http://doi.org/10.1002/anie.202015173
Related URL: http://dx.doi.org/10.1002/anie.202015173
Abstract
Phosphocholine derivative of docetaxel-conjugated lithocholic acid can form stable sub-100 nm nanomicelles (DTX-PC NMs). DTX-PC NMs exhibit superior tolerance and pharmacokinetics over FDA-approved formulation. DTX-PC NMs can retard tumor progression in murine models and induce upregulation of tumor suppressor genes. Superior pharmacokinetic profiling in non-human primates makes them an ideal platform for clinical applications.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 124401 |
| Deposited On: | 19 Nov 2021 07:44 |
| Last Modified: | 19 Nov 2021 07:44 |
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