Ghosh, Subhendu ; Khandelia, Tamanna ; Patel, Bhisma K. (2021) Solvent-Switched Manganese(I)-Catalyzed Regiodivergent Distal vs Proximal C–H Alkylation of Imidazopyridine with Maleimide Organic Letters, 23 (19). pp. 7370-7375. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.1c02536
Related URL: http://dx.doi.org/10.1021/acs.orglett.1c02536
Abstract
A sustainable Mn(I)-catalyzed exclusive solvent-dependent functionalization of imidazopyridine with maleimide via an electrophilic metalation at the distal (in 2,2,2-trifluoroethanol (TFE)) and chelation assisted at the proximal (in tetrahydrofuran (THF)) has been developed. The strategy was successfully applied to the drug Zolimidine and a broad range of substrates, thereby reflecting the method’s versatility.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 124220 |
| Deposited On: | 08 Nov 2021 12:20 |
| Last Modified: | 08 Nov 2021 12:20 |
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